Drug-Drug Interaction (DDI)
Drug-drug interaction (DDI) assessment is often limited by current in vitro and animal models due to short culture duration and species-specific differences. As a result, they fail to capture prolonged induction effects, metabolite buildup, and transporter-driven changes in drug disposition. Javelin Biotech offers a human-relevant liver platform designed to uncover complex DDIs by enabling sustained enzyme and transporter activity over multi-week cultures.
Platform Features Enabling DDI Risk Assessment
Recirculating Medium Flow
Sustained enzyme/transporter activity for 3+ weeks
Metabolite Accumulation
Flexible Protocol & Kinetic Sampling
2-week culture viability without medium change
Parent drug and metabolite profiling
Sustained Metabolic Activity
Chronic exposure
induction/de-induction phases
Capabilities for Predictive DDI Modelling
LTC sustains functional hepatic MPS over weeks and generates longitudinal high-content data from media samples, imaging, and tissue-based assays.
Metabolically active human primary hepatic MPS - qualified primary cells for 15+ day culture
Simultaneous assessment of clinical biomarkers, drug kinetics, tissue responses, -omics analysis
Established protocols for complex multi-cellular human MPS models or develop your own
Javelin supported LTC applications ensure your success
APPLICATIONS ACROSS PRE-CLINICAL DISCOVERY
LTC brings human specificity to preclinical drug testing which is critical for newer therapeutic modalities and delivery systems. LTC’s reproducibility has been validated across multiple pharmaceutical users and labs. It has been used in routine workflows and as a robust human-specific research platform, enabling scientists to ask and answer complex questions that will deliver new mechanistic insights.
Lead optimization
Pharmacokinetics
Toxicology
Drug Delivery/Disposition
Disease Modeling
Target Identification
Target Validation
Target De-risking
JAVELIN DIGITAL TWIN SOFTWARE
Fast and efficient: Design your experiments and analyze data with ease
Accurate predictions: Predict human responses from LTC data
Accelerate lead optimization: Rapidly assess lead candidates with clinical insights and nominate your lead with confidence
Digital Twin Software combines machine learning algorithms with mechanistic modeling for unparalleled insights and improved predictions in pharmacology, pharmacokinetics, and toxicology studies.
JAVELIN LIVER TISSUE CHIP PLATFORM
Focus on your research, not on system set up and maintenance.
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The LTC is designed with ease of use in mind, offering an intuitive user interface for pharmaceutical scientists of all experience levels. The disposable thermoplastic chips provide continuous fluidic recirculation enabling high content data generation. LTCs are quick to set up and easy to manage during a study: no complex tubes or connectors and no frequent media changes.
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This standalone controller fits seamlessly inside your typical CO2 incubator, perfusing up to 4 chips at a time. The sleek design allows up to 6 controllers inside a single incubator. Quickly and easily remove and replace chips for imaging or media sampling. No cumbersome tubing or pump connections involved, saving you valuable time and improving efficiency.
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Fast-track your research with Javelin's on-chip qualified human cells. A Javelin Biokit includes 12 LTCs, qualified human cell vials, and COA with extensive data on morphology, liver specific biomarkers, and CoU-specific characterization.
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Javelin’s software streamlines study design and data analysis. The Hepatic Clearance module quickly turns chip data into human PK predictions.
GET STARTED TODAY
The Javelin Liver Tissue Chip Starter Package includes:
On-site training
LTC chips and controller
Javelin-qualified cells
Established protocols
LIVER TISSUE CHIP BROCHURE
Download the Liver Tissue Chip platform brochure for general information about Liver Tissue Chip, controller, and software in a convenient PDF format. For additional information, please contact info@javelinbio.com.