Liver Tissue Chip
The Javelin Liver Tissue Chip (LTC) sustains functional hepatic MPS over weeks and generates longitudinal high-content data from media samples, imaging, and tissue-based assays.
Supports long term metabolically active hepatic MPS culture with primary human cells.
Offers unparalleled flexibility, allowing you to develop novel assays or adapt existing ones with translational human models
Delivers high-content human relevant data that correlate better with clinical data
Requires minimal training and integrates seamlessly into existing workflows.
LONG-TERM FUNCTIONAL HEPATIC CULTURE
Metabolically active human primary hepatic MPS - qualified primary cells for 15+ day culture
Simultaneous assessment of clinical biomarkers, drug kinetics, tissue responses, -omics analysis
Established protocols for complex multi-cellular human MPS models or develop your own
Javelin supported LTC applications ensure your success
Multi-Organ Chip
The Javelin Multi-Organ Chip (LTC+) integrates a second tissue compartment to the LTC, allowing for the coupling of additional organ models — such as barrier tissues or disease models — with the liver MPS to capture complex multi-organ interactions.
System Components
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The LTC is designed with ease of use in mind, offering an intuitive user interface for pharmaceutical scientists of all experience levels. The disposable thermoplastic chips provide continuous fluidic recirculation enabling high content data generation. LTCs are quick to set up and easy to manage during a study: no complex tubes or connectors and no frequent media changes.
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This standalone controller fits seamlessly inside your typical CO2 incubator, perfusing up to 4 chips at a time. The sleek design allows up to 6 controllers inside a single incubator. Quickly and easily remove and replace chips for imaging or media sampling. No cumbersome tubing or pump connections involved, saving you valuable time and improving efficiency.
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Fast-track your research with Javelin's on-chip qualified human cells. A Javelin Biokit includes 12 LTCs, qualified human cell vials, and COA with extensive data on morphology, liver specific biomarkers, and CoU-specific characterization.
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The Javelin Platform Starter Package includes:
On-site training
LTC chips and controllers
Javelin-qualified cells
Established protocols